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Thompson, Ben, Sharp, Paul, Elliott, Ruan, Al-Mutairi, Sharifah and Fairweather-Tait, Susan J 
ORCID: https://orcid.org/0000-0002-1413-5569
(2010)
Development of a modified Caco-2 cell model system for studying iron availability in eggs.
Journal of Agricultural and Food Chemistry, 58 (6).
pp. 3833-3839.
ISSN 1520-5118
Abstract
A modified Caco-2 cell model system was developed for studying iron availability in mixtures of fresh and/or cooked foods subjected to a simulated gastrointestinal digestion. The effect of combining foods containing high levels of ascorbic acid with cooked eggs on ferritin expression in the cells was measured. There was no detectable increase in ferritin with eggs alone, indicating that none of the iron was available for uptake into the cells, but when mixed with orange juice or salad (lettuce, tomatoes, and red pepper) in ratios similar to those found in meals, there was a significant increase in ferritin concentration (p = 0.0012 and p = 9.2 x 10(-10), respectively); the enhancing effect of salad was greater than orange juice (p = 0.028). These results suggest that the iron in eggs will be more readily absorbed when consumed with foods high in ascorbic acid.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | animals,biological availability,caco-2 cells,chickens,digestion,eggs,humans,iron, dietary,models, biological |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Depositing User: | EPrints Services |
| Date Deposited: | 25 Nov 2010 11:13 |
| Last Modified: | 19 Oct 2023 00:37 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/15106 |
| DOI: | 10.1021/jf904175d |
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