Kinoplastid papain-like cystein peptidases

Caffrey, CR and Steverding, D (2009) Kinoplastid papain-like cystein peptidases. Molecular and Biochemical Parasitology, 167 (1). pp. 12-19. ISSN 0166-6851

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Cysteine peptidases are important for growth and survival of kinetoplastid parasites. The best characterised are those homologous to mammalian cathepsins B and L. To address a somewhat confusing terminology, we introduce a unifying nomenclature for kinetoplastid CATB and CATL peptidases. We review their evolutionary relatedness, genomic organisation, developmental expression, subcellular location and physiological functions. In addition, the applications of kinetoplastid CATB and CATL enzymes as vaccine candidates, diagnostic markers and drug targets are discussed.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Medical Microbiology
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Depositing User: EPrints Services
Date Deposited: 25 Nov 2010 11:13
Last Modified: 03 Sep 2018 11:30
DOI: 10.1016/j.molbiopara.2009.04.009

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