Relation of birth weight, body mass index, and change in size from birth to adulthood to insulin resistance in a female twin cohort

Skidmore, PML, Cassidy, A, Swaminathan, R, Richards, J, Spector, TD and MacGregor, AJ (2008) Relation of birth weight, body mass index, and change in size from birth to adulthood to insulin resistance in a female twin cohort. The Journal of Clinical Endocrinology and Metabolism, 93 (2). pp. 516-520. ISSN 0021-972X

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Abstract

Because an adverse intrauterine environment is thought to induce insulin resistance, our objective was to investigate the relationships between birth weight, BMI, and change in body size over the life course and insulin resistance. SETTING, DESIGN, AND PARTICIPANTS: We conducted a cross-sectional study in a cohort of 1194 female twins aged 18-74 yr. The relationship between birth weight and insulin resistance was analyzed using a regression method allowing for a simultaneous estimation of within- and between-pair influences. The approach allows the influence of individual fetal nutrition on adult insulin resistance to be distinguished from effects that are mediated by confounding factors in the maternal environment.

Item Type: Article
Uncontrolled Keywords: adolescent,adult,aged,birth weight,blood glucose,body mass index,cohort studies,cross-sectional studies,female,humans,infant, newborn,insulin,insulin resistance,linear models,middle aged,twins, dizygotic,twins, monozygotic
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: EPrints Services
Date Deposited: 25 Nov 2010 11:11
Last Modified: 23 Jan 2019 13:38
URI: https://ueaeprints.uea.ac.uk/id/eprint/13698
DOI: 10.1210/jc.2007-1424

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