The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt

Ogunwobi, Olorunseun O and Beales, Ian L P (2007) The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. International Journal of Colorectal Disease, 22 (4). pp. 401-409. ISSN 0179-1958

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Abstract

Obesity is a major risk factor for the development of colon cancer. Secretion of the hormone leptin from adipocytes is increased in obesity, and serum levels are proportional to body fat mass. Serum leptin levels are an independent risk factor for colon cancer. Leptin receptors are expressed in normal, premalignant and malignant colonic epithelia. We have investigated the effects of leptin on proliferation and apoptosis of colonic cancer cells and the early signalling events involved.

Item Type: Article
Uncontrolled Keywords: apoptosis,cell division,cell line, tumor,colonic neoplasms,enzyme activation,humans,intracellular signaling peptides and proteins,jnk mitogen-activated protein kinases,janus kinase 2,leptin,phosphatidylinositol 3-kinases,phosphotransferases,proto-oncogene proteins c-akt
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
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Depositing User: EPrints Services
Date Deposited: 25 Nov 2010 11:10
Last Modified: 25 Jul 2018 05:52
URI: https://ueaeprints.uea.ac.uk/id/eprint/13382
DOI: 10.1007/s00384-006-0181-y

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