Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk

Low, Yen-Ling, Taylor, James I, Grace, Philip B, Mulligan, Angela A, Welch, Ailsa A, Scollen, Serena, Dunning, Alison M, Luben, Robert N, Khaw, Kay-Tee, Day, Nick E, Wareham, Nick J and Bingham, Sheila A (2006) Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk. Nutrition and Cancer, 56 (1). pp. 31-39. ISSN 1532-7914

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Abstract

Prospective phytoestrogen exposure was assessed using both biomarkers and estimates of intake in 89 British men recruited into the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition study, men who subsequently developed prostate cancer. Results were compared with those from 178 healthy men matched by age and date of recruitment. Levels of seven phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin, equol, enterodiol, and enterolactone) were measured in spot urine and serum samples. Five single-nucleotide polymorphisms in COMT, CYP19, ESR1, and SHBG genes were genotyped. Urinary levels of all phytoestrogens correlated strongly with serum levels. Correlation coefficients ranged from 0.63 (glycitein) to 0.88 (daidzein) (P

Item Type: Article
Uncontrolled Keywords: aged,biological markers,diet,genotype,humans,male,middle aged,odds ratio,phytoestrogens,polymorphism, single nucleotide,prospective studies,prostatic neoplasms,risk factors,united states
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Biological Sciences
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Depositing User: EPrints Services
Date Deposited: 25 Nov 2010 11:10
Last Modified: 23 Jan 2019 13:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/13177
DOI: 10.1207/s15327914nc5601_5

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