Dendroid peptide structural mimetics of omega-conotoxin MVIIA based on a 2(1H)-quinolinone core

Guo, Zhao-Xia, Cammidge, Andrew N. ORCID: https://orcid.org/0000-0001-7912-4310 and Horwell, David C. (2000) Dendroid peptide structural mimetics of omega-conotoxin MVIIA based on a 2(1H)-quinolinone core. Tetrahedron, 56 (29). pp. 5169-5175.

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Abstract

Three mimetics of the peptide -Conotoxin MVIIA have been synthesised following the dendroid approach. The three key central amino acids of the natural peptide are mimicked by phenylguanidine (arginine), isopentyl (leucine) and aryl alcohol (tyrosine) attached to a quinolinone core at the 1- and 8-positions. The derivatives are designed to position these key groups in similar spatial orientation to that of the natural peptide in a structure that will have limited conformational flexibility. Key steps of the syntheses involve selective N-alkylation of quinolinone derivatives and guanylation of aryl amines.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017)
Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
Faculty of Science > Research Groups > Chemistry of Light and Energy
Depositing User: Rachel Smith
Date Deposited: 22 Dec 2010 11:17
Last Modified: 19 Oct 2023 01:06
URI: https://ueaeprints.uea.ac.uk/id/eprint/11000
DOI: 10.1016/S0040-4020(00)00179-4

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